Ozempic Dose Titration Calculator
Enter your start date and current dose to see your full titration schedule, nausea risk at each step, and when to expect meaningful results. Based on the FDA-approved semaglutide titration protocol.
How to Read Your Schedule
The standard Ozempic titration protocol was established in the STEP clinical trials. The 0.25 mg starting dose is a tolerability ramp-up dose, not a therapeutic one. Meaningful appetite suppression and weight loss typically begin at 0.5 mg and strengthen at 1 mg and above.
What Each Column Means
- Phase: The named stage in the titration schedule from the FDA prescribing information.
- Dose: The weekly subcutaneous injection dose for that period.
- Duration: How many weeks you remain at this dose before stepping up.
- Nausea Risk: Based on pooled STEP trial data. Risk is highest at the first few dose increases and decreases as the body adapts.
- Therapeutic: Whether this dose level is expected to produce meaningful weight loss based on clinical trial evidence.
Slow Titration and Nausea
If nausea is significantly affecting your quality of life at any dose, staying at that dose for an additional four weeks before escalating is a clinically supported strategy. The slow titration option in this calculator doubles the time at each step. For dietary strategies and timing adjustments that reduce nausea independently of dose changes, see our full guide on managing Ozempic nausea. For an in-depth look at conservative and below-standard dosing approaches, our microdosing Ozempic guide covers the evidence and how to discuss this option with your prescriber.
What This Calculator Does Not Do
This tool shows the standard clinical protocol and does not account for individual factors including side effect tolerance, other medications, medical conditions, or your physician's specific guidance. It is a reference tool, not a prescription. If you have been at a therapeutic dose for several months and are not seeing results, our guide on why Ozempic may not be working covers dose, injection technique, and plateau issues in detail.